Predictive value of 68Ga-PSMA PET/CT for high-risk prostate cancer
10.3760/cma.j.issn.2095-2848.2019.02.004
- VernacularTitle:68Ga-PSMA-617PET/CT对高危前列腺癌的预测价值
- Author:
Chen LIU
1
;
Teli LIU
;
Zhi YANG
;
Ning ZHANG
;
Peng DU
;
Yong YANG
;
Yiqiang LIU
;
Jing WANG
;
Kun YAN
;
Xing YANG
;
Hua ZHU
;
Nan LI
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科、恶性肿瘤发病机制及转化研究教育部重点实验室 100142
- Keywords:
Prostatic neoplasms;
Prostate-specific membrane antigen;
Isotope labeling;
Gallium radioisotopes;
Positron-emission tomography;
Tomography,X-ray computed
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(2):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of 68Ga-prostate specific membrane antigen (PSMA)-617 PET/CT in predicting high-risk prostate cancer.Methods From May 2016 to January 2017,30 patients (median age 67 years) with biopsy-proven prostate cancer were included.The 68Ga-PSMA-617 PET/CT images and clinical data of all patients were analyzed retrospectively.According to prostate cancer risk stratification criteria of National Comprehensive Cancer Network (NCCN) Guidelines (including Gleason scores,prostate specific antigen (PSA)),all patients were classified into low-moderate-risk group and high-riak group.PET images were analyzed semi-quantitatively and maximum standardized uptake value (SUVmax) of primary prostate cancer was measured.SUVmax of 68Ga-PSMA-617 PET/CT was used to establish logistic regression model for predicting high-risk prostate cancer,and the diagnostic efficiency of the model was evaluated by receiver operating characteristic (ROC) curve analysis.Results The median Gleason score of 30 patients was 7.5 (7,9),and the median PSA was 34.0 (19.4,119.1) μg/L,including 9 patients with PSA≤ 20 μg/L and 21 patients with PSA＞20 μg/L.According to the NCCN Guidelines,there were 24 patients with high-risk prostate cancer and 6 patients with low-moderate-risk prostate cancer.SUVmax was higher in high-risk group than that in low-moderate-risk group (14.2 (11.4,23.1) vs 7.9 (3.8,13.1);u =118,P＜ 0.05).Logistic regression model established with SUVmax could effectively predict high-risk prostate cancer with the area under ROC curve of 0.819.When the cut-off value was set as 0.73,the sensitivity and specificity of the model were 87.5％(21/24) and 4/6 respectively.Conclusion SUVmax of 68Ga-PSMA-617 PET/CT can be used as an imaging biomarker for predicting high-risk prostate cancer.
