Characteristics of brain glucose metabolism on 18F-FDG PET imaging in patients with early Parkinson's disease accompanied by visuospatial working memory impairment
10.3760/cma.j.issn.2095-2848.2019.01.004
- VernacularTitle:伴视空间工作记忆障碍的早期帕金森病18F-FDG PET显像脑葡萄糖代谢特点
- Author:
Xiuming LI
1
;
Fengtao LIU
;
Yuyan ZHANG
;
Haibo TAN
Author Information
1. 复旦大学附属华山医院PET中心
- Keywords:
Parkinson disease;
Vision disorders;
Memory disorders;
Memory,short-term;
Positron-emission tomography;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2019;39(1):10-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the characteristics of brain glucose metabolism in patients with early Parkinson's disease (PD) accompanied by visuospatial working memory impairment using 18F-fluorodeoxyglucose (FDG) PET imaging.Methods Between January 2015 and March 2017,early PD patients with visuospatial working memory impairment (14 males,6 females,age:(55.7±6.7) years),early PD patients without visuospatial working memory impairment (13 males,7 females,age:(55.7±8.5) years) and healthy controls (14 males,6 females,age:(54.6±6.4) years) were included.Resting-state 18F-FDG PET was performed to obtain the brain glucose metabolism,Subsequently,statistical parametric mapping (SPM) was used to compare the brain glucose metabolic changes among different groups.Results Compared with the control group,hypermetabolism was observed in putamen,globus pallidus,thalamus,pons,cerebellum and primary motor cortex and hypometabolism was found in part of the occipital and temporal lobe in the groups ofearly PD (Zmax values:3.19-6.86,t values:2.11-9.96,all P＜0.001).The PD group with visuospatial working memory impairment had hypometabolism regions in bilateral lateral prefrontal cortex and posterior parietal cortex compared with the group without visuospatial working memory impairment.Conclusion Abnormal metabolism of glucose in visual processing channels of brain in early PD patients may be one of the causes of visuospatial working memory impairment.
