A Case of Anti-Glomerular Basement Membrane Antibody Associated Crescentic Glomerulonephritis with Positive Antineutrophilic Cytoplasmic Antibody.
- Author:
Kyu Hwan LEE
1
;
Dong Ryeul LEE
;
Kang Hee KIM
;
Jin Hoon CHO
;
Dae Young KIM
;
Jae Sung CHUNG
;
Jin Min KONG
;
Sun Hee YUN
;
Beung Chang KIM
Author Information
1. Department of Internal Medicine, Maryknoll Hospital, Pusan, Korea.
- Publication Type:Case Report
- Keywords:
Anti-GBM antibody;
ANCA;
Glomerulonephritis
- MeSH:
Acute Kidney Injury;
Anti-Glomerular Basement Membrane Disease;
Antibodies, Antineutrophil Cytoplasmic;
Basement Membrane*;
Biopsy;
Cyclophosphamide;
Cytoplasm*;
Female;
Glomerulonephritis*;
Hematuria;
Humans;
Immunoglobulin G;
Kidney;
Middle Aged;
Plasmapheresis;
Pneumonia;
Renal Dialysis
- From:Korean Journal of Nephrology
1999;18(4):656-660
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 63-year-old woman presented to the hospital with gross hematuria and acute renal failure. Kidney function deteriorated rapidly and progressively. A renal biopsy revealed segmental or circumferential crescents associated with linear deposits of immunoglobulin G, typical of anti-glomerular basement membrane disease. Both c-ANCA and anti-GBM antibody were detected in serum. She was treated with hemodialysis, plasmapheresis, high dose steroid and cyclophosphamide. However, she died 7 weeks after treatment because of pneumonia, without recovery of renal function. Serologic positivity of both ANCA and anti-GBM antibody are becoming more frequently recognized in rapidly progressive glomerulonephritis. The influence of c-ANCA on the clinical course of anti-GBM glomerulonephritis remains to be determined.
