Risk factors of intrahepatic recurrence after resection for Barcelona Clinic Liver Cancer stage 0 hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2018.12.001
- VernacularTitle:巴塞罗那0期肝细胞癌患者术后肝内复发危险因素
- Author:
Ruofan SHENG
1
;
Kaipu JIN
;
Xuxiao CHEN
;
Lingli CHEN
;
Shengxiang RAO
;
Mengsu ZENG
Author Information
1. 复旦大学附属中山医院放射科上海市影像医学研究所
- Keywords:
Hepatocellular carcinoma;
Surgery;
Recurrence;
Magnetic resource imaging;
Barcelona Clinic Liver Cancer (BCLC)
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(12):793-796
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of intrahepatic recurrence after resection for Barcelona Clinic Liver Cancer (BCLC) stage 0 hepatocellular carcinoma (HCC).Methods 58 patients with pathologically confirmed BCLC stage 0 HCC treated with liver resection at the Zhongshan Hospital,Fudan University from January to December 2011 were included in this study.The male/female ratio was 50/8.The age ranged from 31 to 72 years.The clinical,pathological and MR imaging features of these patients were analyzed.The recurrence-free survival rates between patients with HCC ≤ 1.5 cm (n=27) and ＞ 1.5 cm (n=31) were compared.The risk factors of intrahepatic recurrence for HCCs were compared using the Cox regression analysis.Results Intrahepatic recurrence was identified in 25 patients,and the median recurrence time was 33 months.The 3-and 5-year cumulative recurrence-free survival rates were 73.0％ (95％CI:60.7％～85.3％) and 52.3％ (95％CI:37.2％～67.4％).No significant differences were found in the recurrence-free survival rates between tumors ≤ 1.5 cm and ＞ 1.5 cm (P＞0.05).Multivariate analyses demonstrated that serum alpha-fetoprotein level ＞20 g/L (HR 3.773,95％CI:1.628～8.745;P＜0.05) and irregular tumor shape (HR 4.584,95％CI:1.485～ 14.155;P＜0.05) were independent risk factors of intrahepatic recurrence.Conclusions Elevated serum alpha-fetoprotein level and irregular tumor shape were associated with an increased risk of intrahepatic recurrence for BCLC stage 0 HCC patients after resection.They could be used as early prognostic indicators in clinical practice.
