Research progress of silent information regulator 1 in hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2018.11.015
- VernacularTitle:沉默信息调节因子1在肝细胞癌中的研究进展
- Author:
Shuwei DANG
1
;
Guodong LI
;
Ming LIU
Author Information
1. 哈尔滨医科大学附属第四医院普外科 普外科生物样本库
- Keywords:
Silent information regulator 1;
Hepatocellular carcinoma;
Signal pathway;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(11):781-785
- CountryChina
- Language:Chinese
-
Abstract:
Primary hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide.At present,the molecular mechanism of the carcinogenesis and development of HCC have not been systematically elucidated.Silent information regulator 1 (SIRT1) is a histone deacetylase,which is dependent on nicotinamide adenine dinucleotide (NAD+).It is involved in many biological processes such as metabolism,oxidative stress,genotoxicity,aging and tumor formation.During the recent years,thefunction of SIRT1 in the carcinogenesis and progress of HCC has attracted wide attention.SIRT1 is abnormally expressed in the development of HCC,and acts as an oncogene.It promotes the proliferation,apoptosis,metastasis and chemotherapy resistance of HCC through multiple molecular pathways including microRNA,AMP-activated protein kinase,Yes-associated protein,telomerase,autophagy,PI3K/Akt and so on.In this article,we discussed the latest research progress of SIRT1 in HCC.
