Laparoscopic splenectomy for patients with idiopathic thrombocytopenic purpura and Helicobacter pylori
10.3760/cma.j.issn.1007-8118.2018.11.010
- VernacularTitle:腹腔镜脾切除联合幽门螺杆菌根治治疗特发性血小板减少性紫癜的临床效果
- Author:
Peiyuan TANG
1
;
Junfeng SONG
;
Kele QIN
;
Xun WANG
;
Hongbin ZHANG
;
Xiong YAN
Author Information
1. 400016,重庆医科大学附属第一医院肝胆外科
- Keywords:
Idiopathic Thrombocytopenic Purpura;
Helicobacter pylori;
Laparoscopi Splenectomy
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(11):766-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the short-term and long-term outcomes of laparoscopic splenectomy combined with eradication of Helicobacter pylori (HP) in patients with idiopathic thrombocytopenic purpura (ITP).Methods 72 patients with ITP were divided into three groups:the eradication of Hp group (group A),the untreated or failure group (group B),and the Hp-negative group (group C).Results Hppositive Patients (group A and group B) were significantly shorter in the course of disease before splenectomy (26.7± 13.8 months vs.45.2±22.1 months,P＜0.05),and lower in platelet counts peak within 7 days after splenectomy (134.9±53.9) × 109/L vs.(250.9± 160.5) × 109/L,P＜0.05) than Hp-negative patients.After discharge from hospital,in 28 patients who received infection therapy against Hp by taking amoxicillin,CLA,omeprazole for one month,21 (75.0％) patients had the Hp eradicated,but in 7 patients the eradication failed.The PLT between these 2 groups of patients were (189.6± 114.8)× 109/L vs.(124.0±45.7) × 109/L,(P＜0.05).The long-term outcomes in platelet counts and remission rates after spleuectomy of the three groups of patients were (149.7±90.6) × 109/L,76.1％ (group A);(98.5±64.1) × 109/L,66.6％(group B);(172.4± 102.0)× 109/L,80.0％ (group C).The platelet count in group B was significantly lower than group C (P＜0.05).There was no statistical significance between group A and group C (P＞0.05).There was no significant difference in the remission rates in the three groups.Conclusions Eradication of Hp improved the short-term and long-term outcomes of Hp-positive ITP patients after splenectomy.
