Relationship between factors of gross tumor volume and locoregional failure of radical intensity-modulated radiation therapy for esophageal carcinoma
10.3760/cma.j.issn.1004-4221.2019.02.002
- VernacularTitle:食管癌根治性调强放疗大体肿瘤体积因素与靶区内放疗失败的关系
- Author:
Jing ZENG
1
,
2
;
Qingsong PANG
;
Wencheng ZHANG
;
Yong GUAN
;
Dong QIAN
;
Ping WANG
;
Pengpeng QU
;
Lujun ZHAO
;
Jun WANG
;
Daquan WANG
;
Xiangyu SHI
;
Xiaojie LIU
Author Information
1. 天津医科大学肿瘤医院放疗科国家肿瘤临床医学研究中心 天津市肿瘤“防治”重点实验室天津市恶性肿瘤临床医学研究中心 300060
2. 天津市中心妇产科医院妇瘤科 300100
- Keywords:
Esophageal carcinoma/radiotherapy;
Intensity-modulated radiation therapy;
Gross tumor volume;
Wall thickness
- From:
Chinese Journal of Radiation Oncology
2019;28(2):85-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the relationship between gross tumor volume (GTV)-related factors including GTV-T volume,the maximum thickness of the esophageal lesion plane and GTV-T volume/length(GTV-T volume divided by the length of the lesion calculated by the number of GTV-T layers) and the locoregional failure of radical intensity-modulated radiation therapy (IMRT) for esophageal carcinoma.Methods A total of 133 patients with esophageal cancer undergoing radical IMRT were enrolled.The factors related to GTV-T including GTV-T volume,the maximum thickness of the esophageal lesions,GTV-T volume/length were calculated.The relationship between GTV-T related factors and local recurrence of tumors was retrospectively analyzed.Results There was positively linear association between the locoregional failure rate of GTV-T and the volume of GTV-T.The volume of GTV-T tumor was 36 cm3,the maximum wall thickness was 2.5 cm,and the GTV-T volume/length was calculated as 5.3 cm2.These critical values could be utilized to predict the risk of locoregional failure of IMRT for esophageal carcinoma.Conclusions The GTV-T factors can be adopted to predict the local control and the risk of locoregional failure of radical IMRT for esophageal carcinoma to certain extent.
