Expression of PD-1hiCXCR5-CD4+T cells in patients with systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2019.01.004
- VernacularTitle:系统性红斑狼疮患者外周血程序性死亡受体1hi CXCR5-CD4+T细胞的表达
- Author:
Shiliang ZHOU
1
;
Ting XU
;
Mingyuan CAI
;
Like ZHUANG
;
Lu ZHANG
;
Jinyun CHEN
;
Peirong ZHANG
;
Rurong SUN
;
Wen XIE
;
Yingchun MA
;
Min WU
Author Information
1. 江苏省常州市第一人民医院(苏州大学附属第三医院)风湿免疫科 213003
- Keywords:
Lupus erythematosus;
systemic;
Programmed death-1hiCXCR5-CD4+ T cells;
Systemic lupus erythem-atosus disease activity index;
Aanti-double-stranded deoxyribonucleic acid antibodies
- From:
Chinese Journal of Rheumatology
2019;23(1):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of peripheral programmed death (PD)-1hiCXCR5-CD4+T cells and its clinical significance in systemic lupus erythematosus (SLE). Methods Peripheral blood PD-1hiCXCR5-CD4+ T cells from 21 SLE patients and 16 healthy controls were examined by flow cytometry. The levels of serum anti-double-stranded deoxyribonucleic acid (dsDNA) antibodies were determined using immunoradiometric as-say. Data were analyzed with t test and Pearson's correlation test. Results The per-centages of PD-1hiCXCR5- cells within CD4+ T cell were significantly higher in SLE patients [(2.1 ±2.0)％] compared to normal controls [(0.3±0.3)％] (t=2.959, P<0.01). The percentages of PD-1hiCXCR5-cells within CD4+T cells in moderate to severe active SLE patients (3.0 ±2.0)％ was significantly increased compared to patients with mild or inactive (1.0±1.4)％(t=2.574, P<0.05) and normal controls (0.3±0.3)％ (t=5.149, P<0.01). The percentages of PD-1hiCXCR5- cells within CD4+ T cells from SLE patients were positively related with systemic lupus erythematosus disease activity index (SLEDAI) (r=0.475, P=0.0297). SLE patients in serum anti-dsDNA antibodies positive group (2.7±2.1)％displayed a higher percentage of PD-1hiCXCR5-cells within CD4+T cells than patients in serum anti-dsDNA antibodies negative group (0.6 ±0.5)％ (t=2.303, P<0.05). The percentages of PD-1hiCXCR5-cells within CD4+T cells from SLE patients were positively correlated with anti-dsDNA antibody titers. Conclusion The percentages of PD-1hiCXCR5- cells within CD4+ T cells from SLE patients are increased and are positively correlated with SLEDAI and anti-dsDNA antibody levels. Increased percentage of PD-1hiCXCR5-cells within CD4+T cells might play an important role in the pathogenesis of SLE.
