Analysis of the relationship between health-related quality of life (primary biliary cholangitis-40) and clinical presentations of patients with primary biliary cholangitis
10.3760/cma.j.issn.1007-7480.2018.12.002
- VernacularTitle:原发性胆汁性胆管炎生活质量指标PBC-40与临床指标相关性分析
- Author:
Shuo ZHANG
1
;
Li WANG
;
Liling ZHAO
;
Jinlei SUN
;
Zhilei CHEN
;
Yihan CAO
;
Tihong SHAO
;
Yunjiao YANG
;
Hua CHEN
;
Yongzhe LI
;
Fengchun ZHANG
Author Information
1. 100730,中国医学科学院北京协和医学院北京协和医院风湿免疫科
- Keywords:
Biliary cholangitis;
Health-related quality of life scores;
Primary biliary cholangitis-40;
Relationship
- From:
Chinese Journal of Rheumatology
2018;22(12):798-801
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the health related quality of life score [primary biliary cholangitis (PBC)-40] in patients with PBC,and the relationship between PBC-40 and clinical presentations.Methods The PBC-40 score and clinical presentations in PBC patients (n=65) were adapted in this study.Patients were divided into the untreated group and the treated group,and the treated group was further divided into ursodesoxycholic acid (UDCA) response group and UDCA non-response group.PBC-40 scores of different groups were analyzed by t-test and the relationship between PBC-40 and clinical presentations were analyzed with Pearson's test.Results Dimensions of PBC-40 scores of this group of patients were as follows:symptoms were (15.8±4.1) points,itch was (4.9±2.8) points,atigue was (23.8±8.9) points,cognitive dysfunction score was (11.4±4.7) points,social activity score was (17.0±7.5) points,and the emotion score was (6.5±3.1) points.The untreated group had higher emotion scores than the treated group (t=2.024,P=0.045).Compared with the UDCA response group,UDCA non-response group had higher scores in cognitive,social and emotion dimension (t =2.126,2.309,2.062,respectively,P=0.039,0.025,0.045,respectively).Itch score was significantly correlated with total bilirubin (TBil),direct bilirubin (DBil),alkaline phosphatase (ALP) and total bile acid (TBA) (r=0.349,0.345,0.324,0.427,respectively,P＜0.01),while the social scores were correlated with TBil,DBil,aspartate aminotransferase (AST) and TBA (r=0.361,0.383,0.316,0.331,P＜0.01) and emotion scores were associated with ALT,TBil,GGT,ALP,AST and TBA (r=0.332,0.430,0.265,0.326,0.297,0.353,P＜0.05).ConclusionPBC-40 can be used as a health-related quality of life assessment for PBC patients inChinese population.Itch,social and emotion dimensions are correlated with clinical activity indicators.Hyperbilirubin,ALP and TBA can predict low health quality of life in PBC patients.Conclusion PBC-40 can be used as a health-related quality of life assessment for PBC patients in Chinese population.Itch,social and emotion dimensions are correlated with clinical activity indicators.Hyperbilirubin,ALP and TBA can predict low health related quality of life in PBC patients.
