Detection S100B, P-Tau and Aβ1-42 proteins in the plasma of rheumatoid arthritis patients with mild cognitive impairment
10.3760/cma.j.issn.1007-7480.2018.10.001
- VernacularTitle:轻度认知功能障碍的类风湿关节炎患者血浆中S100B蛋白过度磷酸化tau蛋白β淀粉样蛋白的检测分析
- Author:
Li YANG
1
;
Qinghua ZOU
;
Yan ZHANG
;
Yin SHI
;
Chunrong HU
;
Caixia HUI
;
Xiaofei LIU
;
Yongfei FANG
Author Information
1. 陆军军医大学第一附属医院中西医结合·风湿免疫中心
- Keywords:
Arthritis,rheumatoid;
Mild cognitive dysfunction;
S100 proteins;
Tau proteins;
Amyloid beta-protein
- From:
Chinese Journal of Rheumatology
2018;22(10):649-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the plasma protein concentration of S100B protein,hyperphosphorylated tau protein (P-tau) and β-amyloid (Aβ1-42) of rheumatoid arthritis (RA) patients with mild cognitive impairment (MCI) and to provide a reference for clinical diagnosis and prevention of cognitive dysfunction of RA patients.Methods The subjects were consisted of three groups:RA patients with MCI,RA patients with normal cognitive function (NC) and healthy controls.The Montreal Cognitive Assessment (MoCA)was used to test patients' cognitive function,generalized anxiety disorder scale-7 (GAD-7) scale and 9-item patient health questionnaire-9 (PHQ-9) were used to exclude anxiety and depression of RA patients.The concentration of S100B protein,P-tau protein and Aβ1-42 protein in plasma was detected by enzyme-linked immunosorbent assay (ELISA),and the correlation among the concentration of S100B protein,P-tau protein and MoCA scores was analyzed by Pearson's chi-squared test.Results ① Cognitive scores showed that some RA patients had MCI.② The plasma levels of S100B (F=11.81,P＜0.05),P-tau (F=3.3,P＜0.05) protein in RA patients with MCI were higher than that in NC RA patients and the control group (P＜0.05).③ The clinical index analysis showed that the concentration of C reactive protein (CRP) in RA patients with MCI was higher than that in NC RA patients and healthy control,the difference was statistically significant (t=6.44,P＜0.05).④The levels of plasma P-tau (r=-0.539,P＜0.05),S100B (r=-0.346,P＜0.05),CRP (r=-0.358,P＜0.05) protein were negatively correlated with cognitive scores (P＜0.05).Conclusion CRP,S100B protein and P-tau protein are associated with the pathogenesis of RA patients with MCI.The consequences of plasma concentration test can be com-bined with cognitive assessment questionnaire to provide reference for clinical diagnosis of RA patients with MCI.
