Quantitative evaluation of fibrosis by geometrical characteristics of hepatic capsule based on ultrasonic images:an experimental study
10.3760/cma.j.issn.1004-4477.2018.12.018
- VernacularTitle:肝包膜超声图像几何特征定量评估肝纤维化的实验研究
- Author:
Jialin SONG
1
;
Xiang LIU
;
Jianquan ZHANG
;
Jiaqi ZHAO
;
Lulu ZHAO
;
Qian PAN
Author Information
1. 海军军医大学 (第二军医大学) 附属长征医院超声科
- Keywords:
Ultrasonography;
Hepatic fibrosis;
Liver cirrhosis;
Geometrical characteristics
- From:
Chinese Journal of Ultrasonography
2018;27(12):1095-1099
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of quantitative evaluation in fibrosis by geometrical characteristics of hepatic capsule based on computer technology . Methods Fifty-nine rabbits models of fibrosis were established and then were divided into four groups according to the results of pathologic examination:S0-S1 ,S2 ,S3 and S4 groups . Two-dimensional high-frequency ultrasound images of hepatic capsule of the rabbits were collected at 6th week ,12th week and 18th week . All the images were collected to obtain the contour line of the capsule and its shape control points by combining manual monitoring and gradient optimization methods . Subsequently ,the mean value and variance of angles between adjacent seed points and the number of continuous segments of the contour line ,were extracted to evaluate the smoothness and continuity of the contour line of the hepatic capsule . Results With aggravating fibrosis ,the mean value and variance of the angles were gradually increased ,and the differences between S0-S1 and other 3 groups were all statistically significant( P <0 .05) . Similarly ,the number of segments required to make the sum of lengths of continuous segments reach up to 80％ of the total width of the imaging section was gradually increased . The differences between S0-S1 and S4 group( P =0 .025) ,S2 and S4 group( P =0 .004) were also statistically significant . Conclusions Analysis of geometrical characteristics of the hepatic capsule partially indicates the presence of early-stage fibrosis ,and is expected to provide a quantitative method for non-invasive assessment of fibrosis .
