Discussion on traditional Chinese medicine intervention mechanism and syndrome differentiation of diabetic kidney disease
10.3969/j.issn.1008-9691.2018.06.001
- VernacularTitle:糖尿病肾病的中医药干预机制及辨证论治思考
- Author:
Ping LI
1
;
Yang HAN
Author Information
1. 天津市中医药研究院附属医院
- Keywords:
Diabetic kidney disease;
Signal pathway;
Syndrome differentiation
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2018;25(6):561-566
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus. The clinical manifestations are glomerular hypertrophy, proteinuria, decreased glomerular filtration and renal fibrosis leading to loss of renal function. Although the exact cause of DKD is unclear, several mechanisms have been hypothesized, such as hyperglycemia-induced hyper-filtration of the kidney and kidney damage, increased oxidative stress induced by advanced glycation end products, activated protein kinase C (PKC) induced cytokines, increased production of chemokines, as well as different signals of inflammation and apoptosis. Among various factors, oxidative stress has been considered to play a major role in the pathogenesis and proliferation of DKD. It triggers several signaling pathways involved in DM, such as PKC cascade, Janus kinase/signal transduction and activating transcription factor (JAK/STAT) signaling, mitogen-activated protein kinase (MAPK), mammalian target of rapamycin (mTOR), etc. Clinical practice showed no matter it is Chinese single herbal medicine or compound Chinese medicine it has a good therapeutic effect. Therefore, how to use Chinese medicine more properly to treat DKD requires us to think over more seriously.
