Expressions and its prognostic value research of MMP-11 and cathepsin-D in gastric adenocarcinoma
10.3760/cma.j.issn.1008-6315.2019.01.006
- VernacularTitle:基质金属蛋白酶11和组织蛋白酶D在胃腺癌组织中的表达及其与预后的关系
- Author:
Aidong LIU
1
;
Shifei LIU
;
Xudong SONG
;
Luyang CHENG
;
Hui TANG
;
Yanjie XIONG
;
Deyan LI
;
Feng YAN
;
Jianyang ZHAO
;
Honghui GUO
Author Information
1. 华北理工大学附属医院病理科
- Keywords:
Gastric adenocarcinoma;
MMP-11;
Cath-D;
Prognosis
- From:Clinical Medicine of China
2019;35(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of Matrix Metalloprotein-11 ( MMP-11 ) and Cathepsin-D(Cath-D),and investigate their relationship and prognostic significance. Methods The study included 95 cases′ clinical date and postoperative specimens of gastric adenocarcinoma ( North China University of Science and Technology Affiliated Hospital,2010. 01-2013. 12) as observation group,70 cases of normal gastric tissue(from observation group) as control group. Expressions of MMP-11 and Cath-D were detected by IHC methods in two groups. Results The positive rate of MMP-11 was 51. 6%( 49/95) in observation group,5. 7%(4/70)in control group(χ2＝38. 884,P＜0. 05). The positive rate of Cath-D was 73. 7%(70/95) in observation group,28. 6%(20/70) in control group(χ2＝33. 082,P＜0. 05). The positive rate of MMP-11 was correlated with metastasis and vascular invasion(χ2＝7. 193、15. 566,P＜0. 05). The positive rate of Cath-D was correlated with maximal diameter,lymph node metastasis,vascular invasion and proliferation index(χ2＝7.431、5.654、6.569、6.801,P＜0.05).There was positive relationship between MMP-11 and Cath-D in observation group(r＝0. 46,P＜0. 05). The expressions of MMP-11 and Cath-D were correlated with prognosis in gastric adenocarcinoma ( P＜0. 05) . Conclusion The higher expressions and synergistic effect of MMP-11 and Cath-D may promote the occurrence and development in gastric adenocarcinoma. The joint detection of MMP-11 and Cath-D may be helpful to predict the prognosis of gastric adenocarcinoma.
