The effect of levonorgestrel-releasing intrauterine system on IGF-Ⅰ and IGF-IR expression after transcervical resection of polyp
10.3760/cma.j.issn.1008-1372.2019.01.013
- VernacularTitle:左炔诺孕酮宫内缓释系统对子宫内膜息肉电切术后IGF-Ⅰ和IGF-IR表达的影响
- Author:
Chunmei MEI
1
;
Meiyan XIA
;
Wenya CAO
;
Lina KE
Author Information
1. 湖北医药学院附属东风医院妇产科
- Keywords:
Levonorgestrel;
Intrauterine devices;
medicated;
Endometrial polyp;
Hysteroscopy;
Insulin-like growth factor Ⅰ;
Receptor,IGF type 1
- From:
Journal of Chinese Physician
2019;21(1):48-50,54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) on insulin-like growth factor-Ⅰ (IGF-Ⅰ) and insulin-like growth factor-Ⅰ receptor (IGF-IR) expression after transcervical resection of polyp (TCRP).Methods 100 cases of endometrial polyps were selected.The control group (n =50) was treated with TCRP only,while the observation group (n =50) was treated with LNG-IUS after TCRP.The scores of pictorial blood loss assessment chart (PBCA),endometrial thickness,recurrence rate,mRNA expression of IGF-Ⅰ and IGF-IR in endometrial tissue were compared between the two groups.Results At 1,3,6,12 months follow-up,the PBAC score and endometrial thickness of observation group were significantly lower than control group (P ≤ 0.05).At 12 months after operation,the mRNA expression levels of IGF-Ⅰ and IGF-IR in the endometrium of the observation group were significantly lower than those of the control group (P ≤ 0.05).After 12 months of follow-up,the recurrence rates of the control group and the observation group were 16.0％ (8/50) and 4.0％ (2/50),respectively.The recurrence rate of the observation group was significantly lower than that of the control group (P ≤ 0.05).Conclusions TCRP combined with LNG-IUS treatment can significantly reduce EP recurrence,and down-regulation of the mRNA expression of IGF-Ⅰ and IGF-IR maybe its possible mechanism.
