Molecular and cellular mechanisms underlying the Stem Cell Educator therapy for the clinical treatment of diabetes

VernacularTitle:干细胞免疫教育临床治疗糖尿病的分子和细胞学机制研究进展
Author: Yong ZHAO ¹ ; Xia LI ; Zhiguang ZHOU
Author Information

1. 美国Hackensack大学医学中心
Keywords: Multipotent stem cells; Immunotherapy; Insulin-secreting cells; Diabetes mellitus
From: Journal of Chinese Physician 2019;21(1):16-18
CountryChina
Language:Chinese
Abstract: Multiple immune dysfunctions and shortage of islet beta cells are two key issues for type 1 (T1D) and type 2 (T2D) diabetes.International multi-center clinical studies and basic research have demonstrated the safety and clinical efficacy of Stem Cell Educator therapy for the treatment of T1D and T2D.CB-SC display multiple immune modulations on T cells,regulatory T cells (Tregs),and monocytes through various molecular mechanisms,such as cell-cell contacting,releasing soluble factors,and correcting the autoimmune memory.Recently,we found that platelet-releasing mitochondria exhibit the immune modulation and can migrate to pancreatic islets and be taken up by islet beta cells,leading to the proliferation and enhancement of islet beta cell functions.These findings reveal new mechanisms underlying Stem Cell Educator therapy and open up new avenues to improve the treatment of diabetes in clinics.