PI3Ks in diabetic cardiomyopathy
10.3760/cma.j.issn.1008-1372.2018.12.053
- VernacularTitle:PI3Ks在糖尿病心肌病中的作用
- Author:
Yang LI
1
;
Lihong WANG
;
Hui CHE
;
Meihua LIANG
;
Xuelian FU
Author Information
1. 150081,哈尔滨医科大学附属第二医院内分泌代谢病科
- Keywords:
1-phosphatidylinositol 3-kinase;
Diabetes complications;
Cardiomyopathies/ET;
Review
- From:
Journal of Chinese Physician
2018;20(12):1916-1918
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy refers to the heart disease without coronary artery disease and hypertension,diabetic patients with ventricular dysfunction.The molecular mechanism of diabetic cardiomyopathy remains unclear.Protein and lipid kinase phosphoinositol 3-kinase (PI3Ks) are thought to regulate cardiac damage in diabetes mellitus.This article reviews the role of PI3K subtypes and downstream signal transduction in the pathogenesis of diabetic cardiomyopathy,including cardiac metabolic regulation,contractility,hypertrophy,cardiomyocyte death and inflammation.
