The role of Toll-like receptor 4 in acute pancreatitis
10.3760/cma.j.issn.2095-4352.2018.12.021
- VernacularTitle:Toll样受体4在急性胰腺炎中的作用
- Author:
Qianying HE
1
;
Weixing WANG
Author Information
1. 430060 湖北武汉,武汉大学人民医院普通外科,消化系统疾病湖北省重点实验室
- Keywords:
Toll-like receptor 4;
Acute pancreatitis;
Mechanism
- From:
Chinese Critical Care Medicine
2018;30(12):1206-1208
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors (TLRs) is a kind of pattern recognition receptor which widely exists on the cell membrane. It is a natural immune system component which can regulate the inflammatory response of the body participating in the signal transduction of cells and play an important role in the endogenous immune response. But the excessive inflammatory reaction initiated by TLRs can make the immune function of the body unbalanced and damage the function of many organs. The earliest discovered TLR4 is a transmembrane protein, almost express in all kinds of cell. Lots of study show it is closely related to the occurrence and development of acute pancreatitis (AP). The role and mechanism of TLR4 in AP will be reviewed in this article.
