Advances in the mechanism of vitamin D affecting autophagy

VernacularTitle:维生素D影响自噬的作用机制研究进展
Author: Lei LIU ¹ ; Jinghui LI ; Chao DENG ; Dandan CHEN
Author Information

1. 中南大学湘雅医学院附属海口医院重症医学科
Keywords: Vitamin D; Autophagy; Inflammatory
From: Chinese Critical Care Medicine 2018;30(11):1103-1106
CountryChina
Language:Chinese
Abstract: Autophagy is a degradative process of eukaryotic cell, which plays a vital role in human health. Autophagy imbalance is associated with many diseases. It has been reported that vitamin D can regulate the autophagy in different levels, including induction, nucleation, as well as elongation to maturation and degradation, which affects the occurrence and development of the disease. However, its action mechanism has not been systematically elaborated, and a deeper understanding of the mechanism of vitamin D-regulated autophagy is helpful to guide the diagnosis and treatment of related diseases. The review described the mechanism of vitamin D affecting autophagy to provide theoretical basis for guiding basic and clinical research.