Research progress of gut microbiota and microbiota-targeted therapy in critical ill patients
10.3760/cma.j.issn.2095-4352.2018.11.018
- VernacularTitle:危重症患者肠道菌群变化及干预措施的研究进展
- Author:
Ruoting XU
1
;
Chuhong TAN
;
Jia YIN
;
Suyue PAN
Author Information
1. 南方医科大学南方医院神经内科
- Keywords:
Critical illness;
Gastrointestinal microbiome;
Prebiotics;
Probiotics;
Fecal microbiota transplantation;
Short-chain fatty acid
- From:
Chinese Critical Care Medicine
2018;30(11):1099-1102
- CountryChina
- Language:Chinese
-
Abstract:
In physiological conditions, a diverse microbiota might enhance host defense. However, the gut microbiota of critically ill patients is characterized by lower diversity, lower abundances of key commensal genera, and overgrowth by one bacterial generation, a state known as dysbiosis. Increasing evidences indicate that microbiota-derived components can reach the systemic circulation from the gut and modulate immune homeostasis. Dysbiosis could have greater consequences for the critically ill patients and might contribute to poor outcome. In this review, we highlighted the crucial role of intestinal microbiota in systemic homeostasis in the critically ill patients and summarized emerging evidence in the field of microbiota-targeted therapies. This would provide new perspective for further establishing the causes and consequences of dysbiosis found in the critically ill patients as well as developing new strategies of intervention.