Role of PI3K/Akt signaling pathway in the innate immune of sepsis
10.3760/cma.j.issn.2095-4352.2018.11.016
- VernacularTitle:PI3K/Akt信号通路在脓毒症固有免疫中的作用
- Author:
Ting ZHOU
1
;
Jiaxin SHI
;
Xiaomin LI
Author Information
1. 徐州医科大学附属连云港医院急诊科
- Keywords:
PI3K/Akt signaling pathway;
Sepsis;
Macrophage;
Neutrophile granulocyte;
Dendritic cell
- From:
Chinese Critical Care Medicine
2018;30(11):1091-1094
- CountryChina
- Language:Chinese
-
Abstract:
Phosphatidylinositol 3 kinase/serine/threonine kinase B (PI3K/Akt) signaling pathway plays a key role in regulating immune response and inflammatory factor release in vitro and in vivo by regulating the activation of downstream signaling molecules, and is closely related to the occurrence and development of sepsis. Innate immune cells play important roles in maintaining the stability of the environment and regulating the immune response during sepsis. This review summarized the PI3K/Akt signaling pathway and its regulation in the sepsis of different types of immune cells in the inflammatory response, apoptosis and other aspects to provide clues and pathways for the prevention and treatment of sepsis.
