Association of cardiac function and homocysteine in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1008-6706.2018.24.002
- VernacularTitle:2型糖尿病患者心功能与同型半胱氨酸水平的相关性研究
- Author:
Chunhuai ZHANG
1
;
Shufeng HUANG
;
Jinjin ZHU
Author Information
1. 慈溪市第六人民医院内分泌科
- Keywords:
Diabetes mellitus,type 2;
Cysteine;
Heart function tests;
Blood glucose;
Hemoglobin A,glycosylated;
Forecasting
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(24):3133-3136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between cardiac function and homocysteine (Hcy) level in type 2 diabetes mellitus (T2DM) patients.Methods From May 2015 to April 2016,120 patients with T2DM in the Sixth People＇s Hospital of Cixi were selected.According to the level of Hcy,the patients were divided into DM group (Hcy level ＜15μmol/L,42 cases) and Hcy+DM group (Hcy level≥15 μmol/L,78 cases).And 50 healthy people were selected as control group.The correlations between various physiological and cardiac functional parameters and Hcy level among the three groups were analyzed.Results The levels of Hcy,HbA1c and FBG in the DM group were significantly higher than those in the control group [Hcy:(11.26 ±2.16)μmol/L vs.(8.24 ±1.25)μmol/L,HbA1c:(7.46 ±1.47)%vs.(5.02 ±1.73)%,FBG:(7.87 ±2.75) mmol/L vs.(5.78 ±2.83)mmol/L,all P＜0.05].The E/A value and LVEF value in the DM group were significantly lower than those in the control group (all P＜0.05).The Hcy,HbA1c,and FBG levels in the Hcy +DM group were significantly higher than those in the DM group,and the E/A value and LVEF value in the Hcy +DM group were significantly lower than those in the DM group (all P ＜0.05 ).Spearman＇s correlation coefficient analysis showed that there was a positive correlation between HbA1c and FBG levels and Hcy levels (r＝0.157,0.112,all P＜0.05),but there was a negative correlation between E/A and LVEF values and Hcy levels (r＝-0.264,-0.394,all P＜0.05).Logistic regression analysis showed that the independent risk factor affecting the E/A and LVEF values was Hcy levels ( P ＝0.015,0.001 ). Conclusion The level of Hcy in patients with diabetes can reflect the status of heart function.The higher the level of Hcy,the worse the heart function.The detection of Hcy level can help to predict and evaluate cardiac function in patients.
