Comparison of effect of propofol and sevoflurane on pulmonary function, inflammatory factors and postoperative pulmonary infection in elderly patients with esophageal carcinoma
10.3760/cma.j.issn.1008-6706.2018.23.013
- VernacularTitle:丙泊酚与七氟烷对老年食管癌根治术患者肺功能、炎性因子及术后肺部感染的影响比较
- Author:
Sufang YANG
1
Author Information
1. 丽水市中心医院麻醉科
- Keywords:
Esophageal Neoplasms;
Esophagectomy;
Propofol;
Sevoflurane;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(23):3038-3041
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of propofol on pulmonary function ,inflammatory factors and postoperative pulmonary infection in elderly patients with esophageal carcinoma ,and to provide data for prevention and control of nosocomial infection.Methods From January 2011 to December 2015,155 elderly patients with esophageal cancer in Lishui Central Hospital were selected and randomly divided into control group (C group,n＝70) and obser-vation group (O group,n＝85) according to the digital table.In the maintenance of anesthesia ,O group was given propofol,C group was given sevoflurane.The alveolar arterial oxygen partial pressure difference ( PA -aO2), respiratory index(RI) and oxygenation index (OI) of the two groups were observed at different time points.The levels of IL-1,IL -6 and IL -10 in serum were measured at different time points ,and the pulmonary infections were observed after operation.Results At 30min,60min,90min after ventilation in the two groups ,the PA-aO2,RI were higher than the beginning of mechanical ventilation ,OI were lower than the beginning of mechanical ventilation (t＝7.266,23.451,9.572,8.009,30.836,17.158,4.908,21.237,21.350,7.010,23.644,10.039,9.099,34.254, 16.679,8.217,35.434,22.160,all P＜0.05).At 60min,90min after ventilation,the RI of O group were lower than those in C group(t＝6.613,9.522,all P＜0.05).The levels of IL -1,IL-6 and IL-10 in the two groups after opeation were higher than before operation (t＝5.069,8.903,9.184,14.896,12.137,11.202,all P＜0.05).The IL-1,IL-6 and IL-10 levels in O group after operation were lower than those in C group ,the IL-1 level at 6h postoperation in O group was lower than that in C group (t＝10.442,4.803,2.513,4.076,all P＜0.05).There were 13 cases of nosocomial pulmonary infection in all the 155 patients,the infection rate was 8.39%.There was no statis-tically significant difference in the infection rate between the two groups [6 cases(7.06%) in O group,and 7 cases (10%) in C group,χ2＝0.432,P＞0.05].Conclusion Elderly patients with esophageal cancer undergoing radical operation of propofol ,the effects of propofol on pulmonary function ,inflammatory factors are less,the incidence of postoperative pulmonary infection is low,it has good clinical application value.
