Influence of sufentanil doses difference on sedation,analgesia effects and risk of adverse effects in patients undergoing elective orthopedics operation
10.3760/cma.j.issn.1008-6706.2018.23.006
- VernacularTitle:舒芬太尼使用剂量差异对髋关节置换术后患者镇静镇痛效果及不良反应风险的影响
- Author:
Quanhua LIU
1
;
Rongting GAO
Author Information
1. 舟山医院麻醉科
- Keywords:
Arthroplasty,replacement,hip;
Dose-response,drug;
Analgesia;
Sufentanil
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(23):3012-3015
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of opioids drug doses difference on sedation ,analgesia effects and risk of adverse effects in patients undergoing elective orthopedics operation .Methods From January 2015 to January 2017, 120 patients undergoing elective orthopedics operation in Zhoushan Hospital were chosen and randomly divided into 3 groups according to the digital table ,including low dose group (40 patients) with sufentanil of 0.1μg/kg,moderate dose group(40 patients) with sufentanil of 0.15μg/kg,and high dose group(40 patients) with sufentanil of 0.2μg/kg.The VAS score and Ramsay score after operation ,analgesic drugs addition rate ,addition dose and incidence of adverse effects among 3 groups were compared.Results The VAS scores of the moderate dose group and high dose group at 1h,6h and 12h after operation were significantly lower than those of the low dose group (t＝3.5,3.72,4.19,4.33,3.10,2.43,all P＜0.05).There were no statistically significant differences in Ramsay score after operation among 3 groups(F＝1.02,0.47,0.75,0.94,all P＞0.05).The analgesic drugs addition rate and addition dose of the low dose group were 22.50%,(78.28 ±9.54)mg,respectively,which of the moderate dose group were 7.50%,(63.50 ±6.02) mg,respectively,which of the high dose group were 5.00%,(62.74 ±5.88) mg, respectively.The analgesic drugs addition rate and addition dose of moderate dose group and high dose group were significantly lower than those of the low dose group (χ2/F＝7.48,8.33,3.26,3.41,all P＜0.05).The incidence rate of adverse effects in the high dose group was significantly higher than those in the low dose group and moderate dose group(χ2＝8.12,12.96,7.95,12.02,all P ＜0.05).Conclusion Compared with sufentanil of 0.1μg/kg and 0.2μg/kg,the sufentanil of 0.15 μg/kg on patients undergoing elective orthopedics operation has better analgesia effect.
