Expression and clinical significance of melanoma antigen-encoding gene A1 protein in esophageal squamous cell carcinoma
10.3760/cma.j.issn.1673-4904.2019.01.010
- VernacularTitle:黑素瘤抗原编码基因A1蛋白在食管鳞状细胞癌中的表达及其临床意义
- Author:
Chengxiang ZHU
1
;
Yue YU
;
Haisheng FANG
;
Chenjun HUANG
;
Fei ZHAO
;
Yue ZHOU
;
Jun LI
;
Qifan LI
;
Yu ZHUANG
;
Wei WANG
Author Information
1. 南京医科大学第一附属医院胸外科 210029
- Keywords:
Esophageal neoplasms;
Prognosis;
Melanoma antigen- encoding gene A1 protein;
Cancer-testis antigen
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of melanoma antigen- encoding gene (MAGE) A1 protein in esophageal squamous cell carcinoma, and explore its correlation with the clinicopathological factors and prognosis. Methods A retrospective analysis was performed on 197 patients with esophageal squamous cell carcinoma who accepted radical surgical treatment from January 2006 to December 2012. The expressions of MAGEA1 protein in these specimens of cancer tissue and cancer adjacent tissue were detected by immunohistochemistry with tissue microarray technology. Results MAGEA1 protein was expressed in cytoplasm and nucleus of tumor cells. The positive expression rate of MAGEA1 protein in cancer tissue was significantly higher than that in cancer adjacent tissue: 73.6％ (145/197) vs. 5.6％ (11/197), and there was statistical difference (P<0.01). The positive expression of MAGEA1 protein had no correlations with sex, age, history of smoking/drinking, family history of upper gastrointestinal cancer, depth of tumor invasion, lymph node metastasis, tumor differentiation, location and TNM stage (P>0.05). Kaplan-Meier survival analysis result showed that the 5-year survival rate in patients with MAGEA1 protein positive expression was significantly lower than that in patients with MAGEA1 protein negative expression (37.2％ vs. 53.8％), and there was statistical difference (P=0.018). Multivariate analysis result showed that MAGEA1 protein positive expression was an independent predictor of prognosis in esophageal squamous cell carcinoma patients (HR=1.91, 95％CI 1.22 to 2.98, P = 0.004). Conclusions The expression of MAGEA1 protein is abundant in esophageal squamous cell carcinoma, and is related to worse clinical outcome. MAGEA1 protein could be a candidate target for tumor immunotherapy.
