Advances of Butorphanol in Clinical Research
10.3760/cma.j.issn.1673-4904.2018.12.025
- VernacularTitle:布托啡诺近期的临床研究进展
- Author:
Lina CHEN
1
;
Meiyue TAN
;
Qianyun TAO
;
Youzhuang ZHU
;
Jun CHAI
Author Information
1. 中国医科大学附属盛京医院麻醉科
- Keywords:
Butorphanol;
Preemptive analgesia;
κ-opioid receptor agonist;
General anesthesia;
Review
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(12):1147-1152
- CountryChina
- Language:Chinese
-
Abstract:
Pain is a common and crucial problem in clinical practice, because it has a profound influence on patients in perioperative period. Butorphanol, among plenty of analgesics, is widely used in clinical trials for its various advantages and better analgesic effects. As a typical agonist-antagonist opioid analgesic agent, butorphanol, however, shows different clinical manifestations with different affinity for opioid receptors 25∶4∶1 (κ∶μ∶δ). Besides, butorphanol provides remarkable analgesic and sedative effect in preemptive analgesia, induction and recovery period in general anesthesia, and postoperative analgesia And it could be as a adjuvant to local anaesthesia either. Compared with other opioid drugs, butorphanol is less likely to have side effect on respiratory depression. In addition, its physical dependence is extremely low.
