Preliminary investigation about graded evaluation of neuroendocrine function for patients with craniopharyngioma
10.3760/cma.j.issn.1673-4904.2018.12.015
- VernacularTitle:颅咽管瘤患者神经内分泌功能受损分级评价的初步探索
- Author:
Yao WANG
1
;
Liyong ZHONG
Author Information
1. 100050,首都医科大学附属北京天坛医院内分泌科
- Keywords:
Craniopharyngioma;
Hypothalamus;
Pituitary-target gland axis;
Neuroendocrine function;
Function graded evaluation
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(12):1114-1118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the strategy for grading evaluation of neuroendocrine deficiencies in patients with craniopharyngioma. Methods According to published research literature of Beijing Tiantan Hospital and related guidelines and book, the neuroendocrine deficiencies in patients with craniopharyngioma and variables for evaluation were defined. The evaluation criteria according to weighted scores was established. The neuroendocrine deficiencies were graded into 4 levels. Grad 0 standed for normal neuroendocrine function. Grade 3 standeds for the most severe neuroendocrine impairement. Thirty-seven patients who were diagnosed with craniopharyngioma pathologically after neurosurgery were consecutively recruited. The neuroendocrine function was graded according to the variables and grading strategy during hospitalization. Results In this study, the patients with neuroendocrine deficiencies were graded into 0, 1, 2 and 3 accounting for 0, 18.9%(7/37), 67.6% (25/37) and 13.5%(5/37) respectively. Impairment of hypothalamic function was present in each grade. The patients with more hypothalamic function impairment had more severe manifestations. Diabetes insipidus was the most frequent hypothalamic impairment. Pituitary-target glands function impairment had even distribution in patients with each grade, while the proportion of patients with hyperprolatinemia (stalk effect) gradually increased with the grade level. Conclusions The evaluation criteria and function grading system can be used to evaluate the degree of neuroendocrine deficiencies effectively in patients with craniopharyngioma, and also to evaluate the impairment of hypothalamic function and impairment of pituitary-target glands function.
