Comparative study on the effects of urapidil and sodium nitroprusside on blood pressure in patients with hypertensive intracerebral hemorrhage
10.3760/cma.j.issn.1673-4904.2018.12.006
- VernacularTitle:乌拉地尔与硝普钠对高血压脑出血患者降压效果的对比研究
- Author:
Dongyuan LIU
1
;
Hao WANG
;
Hongbing ZHANG
;
Ziming HOU
;
Jun YANG
Author Information
1. 101149,首都医科大学附属北京潞河医院神经外科
- Keywords:
Intracerebral hemorrhage,hypertensive;
Urapidil;
Sodium nitroprusside
- From:
Chinese Journal of Postgraduates of Medicine
2018;41(12):1077-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of urapidil and sodium nitroprusside on blood pressure and prognosis in patients with hypertensive intracerebral hemorrhage. Methods One hundred and fifty patients with hypertensive intracerebral hemorrhage from January to December 2017 were divided into urapidil group and sodium nitroprusside group according to the medication, each group with 75 patients. The changes of blood pressure, heart rate, hematoma size and neurological function were compared between the two groups. Results At 10 and 30 min after treatment, the systolic blood pressure and diastolic blood pressure of patients in urapidil group were lower than those in sodium nitroprusside group (P＜0.05). At 60 min after treatment , there was no significant difference on blood pressure between the two groups (P＞0.05). At 10, 30, 60, 120 and 240 min after treatment, the heart rate of patients in urapidil group were significantly lower than those in sodium nitroprusside group (P＜0.05). At 24 and 72 h after treatment, there was no notable difference in the size of hematoma between the two groups (P＞0.05). At 1 month after treatment, the neurological scores between the two groups were significantly different: (10.1 ± 2.1) scores vs. (13.8 ± 5.9) scores, P＜0.05. Conclusions Urapidil can effectively control blood pressure in patients with hypertensive intracerebral hemorrhage. Moreover, it exerts better long-term neuroprotective effect, compared with sodium nitroprusside.
