A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages.
- Author:
Kyung Jong WON
1
;
Sung Won PARK
;
Seunghoon LEE
;
Il Keun KONG
;
Jung Il CHAE
;
Bokyung KIM
;
Eun Jong LEE
;
Dong Ku KIM
Author Information
- Publication Type:Original Article
- Keywords: TLT-6; ITIM motif; Anti-proliferation; Macrophages; TREM family
- MeSH: Adaptive Immunity; Computational Biology; Computer Simulation; Cytoplasm; Hematopoietic Stem Cells; Humans; Immunoglobulins; Macrophages*; Macrophages, Peritoneal; Monocytes; Myeloid Cells*
- From:Immune Network 2015;15(5):232-240
- CountryRepublic of Korea
- Language:English
- Abstract: The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.
