The function of αA-crytstallin and effects in ocular diseases
10.3760/cma.j.issn.2095-0160.2019.02.015
- VernacularTitle:αA晶状体蛋白的功能及其在相关眼部疾病中的作用
- Author:
Qiong XU
1
Author Information
1. 北京大学人民医院视网膜脉络膜疾病诊治研究北京市重点实验室 北京大学医学部眼视光学院 北京大学人民医院眼视光中心 100044
- Keywords:
αA-crystallin;
Ocular diseases;
Function;
Distribution;
Structure
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(2):149-154
- CountryChina
- Language:Chinese
-
Abstract:
αA-crystallin is an important protein in lens,with molecular chaperone founction,apoptosis regulation effect,neovascularization regulation,oxidation-reduction reaction process regulation and inflammation reaction regulation.Now,more and more studies have verified that αA-crystallin exists not only in lens,but also in other intraocular structures,such as retina.αA-crystallin can not only maintain the internal environment homeostasis,but also participate in many other eye diseases,such as optic nerve injury diseases,retinal degeneration,ocular neoplasmas,inflammatory diseases and retinal choroidal vascular diseases.This article reviewed the distribution,structure and founction of αA-crystallin and its effects in ocular diseases.
