The function and potential mechanism of the Wnt signaling pathway in retina development and retinal diseases
10.3760/cma.j.issn.2095-0160.2019.02.014
- VernacularTitle:Wnt信号传导通路在视网膜发育及视网膜疾病中的作用及其机制
- Author:
Jing YANG
1
Author Information
1. 天津医科大学眼科医院 天津医科大学眼科研究所 300384
- Keywords:
Wnt signaling pathway;
Retina;
Development;
Retinal diseases
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(2):144-148
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signaling pathway plays a key role in regulating embryonic development and organism growth,which maintains normal physiological function of many tissues and organs.A variety of diseases involve the abnormal activation or inhibition of Wnt signaling pathway.At the stage of retinal development,Wnt signaling pathway is implicated in regulating the formation of retinal field,the maintenance of retinal lamination and the sustentation of retinal stem cell properties,moreover,it is closely related to the development of retinal vessels.Wnt signaling pathway is associated with the development and progression of some retinal diseases,such as familial exudative vitreoretinopathy,age-related macular degeneration,retinoblastoma and diabetic retinopathy.The function and potential mechanism of the Wnt signaling pathway in retina development and retinal diseases were summarized in this review.
