Diagnostic value of combined detection of heart type fatty acid binding protein and brain natriuretic peptide for patients with chronic heart failure
10.3969/j.issn.1008-0074.2018.06.22
- VernacularTitle:联合检测心型脂肪酸结合蛋白、脑钠肽对慢性心力衰竭的诊断价值
- Author:
Xing-Ze JIA
1
;
Ting-Li ZHAO
;
Jing GAO
;
Rong LIN
;
Xiao-Man LIU
Author Information
1. 冀中能源邢台矿业集团有限责任公司总医院心内科
- Keywords:
Heart failure;
Fatty acid-binding proteins;
Natriuretic peptide,brain;
Heart-type fatty acid binding protein;
Brain natriuretic peptide
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2018;27(6):703-707
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study diagnostic value of combined detection of heart type fatty acid binding protein (H-FABP) and brain natriuretic peptide (BNP) for chronic heart failure (CHF) in aged patients.Methods:A total of 178 aged CHF patients hospitalized in our hospital from Jul 2015 to Jun 2016 were selected.According to NYHA cardiac function classification,they were divided into class Ⅱ group (n＝70) and class Ⅲ ～ Ⅳ group (n＝48).An-other 52 aged healthy subjects undergoing physical examination were selected as healthy control group simultaneous-ly.Plasma BNP,H-FABP levels,LAD,LVESd,LVEDd,IVST and LVEF were measured and compared among three groups.Correlation among plasma BNP,H-FABP levels and above cardiac function indexes were analyzed.Results:Compared with healthy control group,there were significant rise in plasma levels of BNP [ (50.65 ± 5.86) ng/L vs.(212.65 ± 17.12) ng/L vs.(1264.73 ± 119.74) ng/L] and H-FABP [ (1.68 ± 0.36) ng/ml vs.(3.34 ± 0.56) ng/ml vs.(9.64 ± 1.27) ng/ml],LAD [ (3.25 ± 0.29) cm vs.(4.98 ± 0.23) cm vs.(5.48 ± 0.51) cm],LVESd [ (28.68 ± 2.7) mm vs.(40.98 ± 4.55) mm vs.(58.63 ± 5.75) mm],LVEDd [ (43.22 ± 4.29) mm vs.(56.63 ± 5.23) mm vs.(61.33 ± 6.07) mm] and IVST [ (8.15 ± 0.68) mm vs.(11.87 ± 1.03) mm vs.(15.93 ± 1.43) mm],and significant reduction in LVEF [ (64.84 ± 6.39)% vs.(49.76 ± 4.76)% vs.(35.76 ± 3.62)%] in NYHA class Ⅱ group and NYHA class Ⅲ ～ Ⅳ group;compared with NYHA class Ⅱ group,there were significant rise in plasma levels of BNP and H-FABP,LAD,LVESd,LVEDd and IVST,and significant reduction in LVEF in NYHA class Ⅲ ～ Ⅳ group,P＝0.001 all.Spearman correlation analysis indicated that plasma BNP,H-FABP levels were significant positively correlated with LAD,LVESd,LVEDd and IVST (r＝0.53～0.71,P＝0.001 all),and significant inversely correlated with LVEF (r＝ -0.54,-0.65,P＝0.001 both);plasma BNP level was signifi-cantly positive correlated with H-FABP level (r＝0.36,P＝0.04).Conclusion:Combined detection of BNP and H-FABP contributes to diagnosing CHF in aged patients and assessing its severity.
