Observation of tigecycline administration in gram-negative bacteria infected children with ventilator-associated pneumonia
10.3760/cma.j.issn.1673-4912.2019.01.011
- VernacularTitle:替加环素在儿童革兰阴性菌感染的呼吸机相关性肺炎中的应用观察
- Author:
Sheng YE
1
;
Jia YU
;
Chenmei ZHANG
;
Shupeng LIN
Author Information
1. 浙江大学医学院附属儿童医院重症监护室
- Keywords:
Tigecycline;
Ventilator-associated pneumonia;
Pediatric intensive care unit;
Multidrug resistant;
Acinetobacter baumanmii
- From:
Chinese Pediatric Emergency Medicine
2019;26(1):46-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of tigecycline therapy in children with ventilator-associated pneumonia infected by gram-negative bacteria. Methods We conducted a restrospective chart review of children with ventilator-associated pneumonia in a tertiary hospital from May 1,2012 to April 30,2017. Inclusion criteria:positive sputum culture result;receiving tigecycline administration of at least 2 days (4 doses). Clinical data and laboratory results were recorded before and after the therapy. Results Twenty-seven children were enrolled,with the in-hospital mortality of 37. 0％(10/27). Twenty-seven bacteri-a strains were recorded,all of which were gram-negative,with Acinetobacter baumanmii took up the most. Most bacteria were susceptible to tigecycline. Median duration of tigecycline was 10 days ( 3-27 days ) , 40. 7％ patients(11/27) got clinically improvement and 44. 4％(12/27) got pathogen eradication. Sulpera-zone was the most concomitantly used antibiotics. Totally 3 dosage models were observed and model 1(load-ing dose 2 mg/kg,maintain dose 1 mg/kg) and model 2 ( loading dose 1. 5 mg/kg,maintain dose 1 mg/kg) were the primary. Rate of clinical improvement and microbiology eradication in model 1 group was higher than other groups. No serious adverse effect was detected. Conclusion Tigecycline combined with other a-gents could be used as salvage therapy in gram-negative bacteria infected ventilator-associated pneumonia children and it is tolerated.
