A Case of Human Herpes Virus-8 Unrelated Primary Effusion Lymphoma-Like Lymphoma Presented as Pleural Effusion.
10.4046/trd.2012.73.6.336
- Author:
Kyung Ho KIM
1
;
Ji Hyun LEE
;
Hye Cheol JEONG
;
Gun Woo KIM
;
Sang Hee SONG
;
So Young JUNG
;
Gwang Il KIM
;
Eun Kyung KIM
Author Information
1. Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Korea. imekkim@hanmail.net
- Publication Type:Case Report
- Keywords:
Lymphoma, Primary Effusion;
Herpesvirus 8, Human;
Pleural Effusion
- MeSH:
B-Lymphocytes;
Biopsy;
Female;
Herpesvirus 4, Human;
Herpesvirus 8, Human;
HIV;
Humans;
Lymphoma;
Lymphoma, Primary Effusion;
Mucin-1;
Pleural Effusion;
Prognosis;
Serologic Tests;
Thorax
- From:Tuberculosis and Respiratory Diseases
2012;73(6):336-341
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary effusion lymphoma (PEL) is a rare type of lymphoma that arises in the body cavity without detectable masses. It is associated with human herpes virus-8 (HHV-8), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV). Recently, PEL unrelated to viral infection has been reported and it has been termed HHV-8 unrelated primary effusion lymphoma-like lymphoma (HHV-8 unrelated PEL-like lymphoma). Here, we report a case of HHV-8 unrelated PEL-like lymphoma in an 80-year-old woman. Chest X-ray and computed tomography revealed left-sided pleural effusion. Pleural effusion analysis and mediastinoscopic biopsy showed atypical cells that had originated from the B cells. The cells were positive for CD20 and bcl-2, but negative for CD3, CD5, CD21, CD30, CD138, epithelial membrane antigen, and HHV-8. Serological tests for HIV and EBV were negative. Considering the patient's age, further treatments were not performed. She has shown good prognosis without chemotherapy for more than 18 months.
