Relationship between human papillomavirus infection and prognosis of lung cancer:A meta-analysis
10.11904/j.issn.1002-3070.2018.06.008
- VernacularTitle:人乳头状瘤病毒感染与肺癌预后相关性的Meta分析
- Author:
Yalong WANG
1
;
Zhangyan LYU
;
Fan ZHANG
;
Xiaoshuang FENG
;
Luopei WEI
;
Xin LI
;
Yan WEN
;
Yushun GAO
;
Qi XUE
;
Shugeng GAO
;
Fengwei TAN
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院 北京 100021
- Keywords:
Human papillomavirus virus;
Lung neoplasms;
Adenocarcinoma;
Prognosis;
Meta-analysis
- From:
Practical Oncology Journal
2018;32(6):520-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objective of this study was to explore the association between human papillomavirus( HPV) and prognosis of lung cancer by meta-analysis. Methods The PubMed,Embase and Cochrane literature databases studies were searched using a combination of subject terms and free words. As of October 2018,a total of 123 related documents were obtained. After screen-ing the literature according to inclusion and exclusion criteria,the basic information of the study,HPV detection methods,lung cancer patients,hazard ratio(HR)values and 95% confidence interval(CI)were extracted from each study. The meta-analysis of random effects models was used to evaluate the correlation between HPV infection and prognosis in patients with lung cancer. Heterogeneity was assessed using the Q test and I2statistics,and publication bias was tested using Egger′s linear regression test and Begg′s rank cor-relation test. Results The study finally included 11 articles(9 in Asia,2 in Europe and US),and 1439 patients with lung cancer. Meta-analysis using a random-effects model showed no significant association between HPV infection and prognosis of lung cancer (HR=0. 90,95% CI:0. 71~1. 13). A stratified analysis of lung cancer pathological subtypes showed that the prognosis of patients with HPV-infected lung adenocarcinoma was significantly better than that in patients without HPV-infected lung adenocarcinoma (HR=0. 65,95% CI:0. 49~0. 85). Sensitivity analysis was performed by sequentially removing the included studies,and the results were not statistically significant. The results of Egger′s test(P=0. 708)and Begg′s test(P=0. 784)suggest that there is no publica-tion bias in this study. Conclusion HPV infection may be related to the prognostic of patients with lung adenocarcinoma. More basic and clinical studies are needed to further explore the association between HPV infection and lung adenocarcinoma as well as the corre-sponding mechanisms in the future.
