Effect of hemodialysis combined with blood perfusion and comprehensive nursing intervention on the levels of interleukin-6, C-reactive protein and β2-microglobulin in patients with diabetic nephropathy
10.3760/cma.j.issn.1672-7088.2019.02.004
- VernacularTitle:血液透析联合血液灌注及综合护理干预对糖尿病肾病患者白介素-6、C反应蛋白和β2-微球蛋白水平的影响
- Author:
Jin YAN
1
;
Li CAO
;
Bingbing XUE
Author Information
1. 江苏省盐城市第一人民医院血液净化中心 224000
- Keywords:
Diabetic nephropathy;
Hemodialysis;
Hemopurification;
Nursing care;
Inflammation
- From:
Chinese Journal of Practical Nursing
2019;35(2):97-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hemodialysis combined with hemopurification and comprehensive nursing intervention on the levels of interleukin -6 (IL-6), C-reactive protein (CRP) and β2- microglobulin (β2- MG) in patients with diabetic nephropathy (DN). Methods A total of 68 patients with DN were selected in our hospital, and were treated with hemodialysis combined with hemopurification. The control group was treated with routine nursing intervention, and the observation group was given comprehensive nursing intervention, with 34 cases in each group. The differences in the levels of IL- 6, CRP and β2- MG before and after treatment were compared between the two groups. Results In the control group, the level of IL-6 before treatment [(121.85±34.95) pg/ml] and 1 month after treatment [(120.53 ± 24.95) pg/ml] and 3 months [(119.05 ± 25.73) pg/ml] showed no significant difference (P>0.05). The level of IL-6 in the observation group for 1 month after treatment [(98.90±20.52) pg/ml] and 3 months [(70.32 ± 10.43) pg/ml] was significantly lower than that before treatment, and significantly lower than those in the control group (P<0.05). There was no significant difference in the level of CRPbetween the control group before treatment [(12.64 ± 3.08) mg/L] and 1 month after treatment (12.64±3.15) mg/L] and 3 months [12.89±4.02] mg/L] (P>0.05); the level of CRP at 1 month after treatment [(9.24 ± 3.24)mg/L] and 3 months after treatment [(7.04 ± 2.54)mg/L] in the observation group was significantly lower than that before the treatment, and significantly lower than those in the control group (P<0.05).The level of β2-MG in the control group at 1 month [(10.24±1.79) mg/L] and 3 months after treatment [(9.01 ± 1.47) mg/L] were significantly lower than before the treatment (12.53 ± 3.45) mg/L];thelevel of β2-MG at 1 month [(9.03±1.68) mg/L] and 3 months after treatment [(6.73±1.73)mg/L] in the observation group was also significantly lower thanthat before the treatment, and significantly lower than those in the control group (P<0.05). Conclusions Hemodialysis combined with hemopurification and comprehensive nursing intervention can effectively inhibit the release of inflammatory factors and reduce the inflammatory state, so it has good clinical application value.
