Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema.
- Author:
Mi Young AHN
1
;
Jea Woong HAN
;
Hyung Joo YOON
;
Jae Sam HWANG
;
Yun Eun YOUNG
Author Information
1. Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Suwon, Korea. amy@rda.go.kr
- Publication Type:Original Article
- Keywords:
Edema;
Bumblebee alcohol extract
- MeSH:
Animals;
Edema;
Endothelial Cells;
Larva;
Pulmonary Artery;
Pupa;
Rats;
Vasodilation
- From:Toxicological Research
2012;28(4):249-253
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.
