Zearalenone Affects Immune-Related Parameters in Lymphoid Organs and Serum of Rats Vaccinated with Porcine Parvovirus Vaccine.
- Author:
Byung Kook CHOI
1
;
Joon Hyung CHO
;
Sang Hee JEONG
;
Hyo Sook SHIN
;
Seong Wan SON
;
Young Keun YEO
;
Hwan Goo KANG
Author Information
1. Toxicology & Residue Chemistry Division, Animal, Plant and Fisheries Quarantine and Inspection Agency, Anyang, Korea. kanghg67@korea.kr
- Publication Type:Original Article
- Keywords:
Zearalenone;
Wistar rat;
Immune parameters;
Cytokines;
Immunoglobulin
- MeSH:
Animals;
Antibody Formation;
Cytokines;
Drinking Water;
Granulocyte-Macrophage Colony-Stimulating Factor;
Immunoglobulin A;
Immunoglobulin E;
Immunoglobulin G;
Immunoglobulin M;
Immunoglobulins;
Interleukin-1;
Interleukin-10;
Interleukin-2;
Interleukin-6;
Lymph Nodes;
Parvovirus, Porcine;
Rats;
Spleen;
Thymus Gland;
Tumor Necrosis Factor-alpha;
Vaccination;
Zea mays;
Zearalenone
- From:Toxicological Research
2012;28(4):279-288
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rats were administered zearalenone (ZEA) via gavage at dosages of 0, 1, 5, and 30 mg/kg for 36 days. On treatment day 8, inactivated porcine parvovirus vaccine (Vac) was injected intraperitoneally. Antibody production against porcine parvovirus was then measured as a function of ZEA treatment. Compared to the vaccine alone, ZEA treatment, with or without Vac, decreased the serum level of IgG. The level of IgM decreased in all ZEA groups at day 22, but the decrease was sustained only in the medium-dose ZEA group at day 36. The level of IgA was unchanged in the Vac only and ZEA groups at day 22, but was decreased in the 5 mg/kg ZEA plus Vac group compared to the Vac only group at day 36. The level of IgE was decreased by all doses of ZEA at day 22, but was unaffected in ZEA plus Vac groups compared to the Vac only group. The levels of IL-1 in the thymus and spleen; INF-gamma in serum; IL-2, IL-6, and IL-10 in the thymus; and IL-10 and IFN-gamma in the spleen decreased after ZEA administration. Furthermore, the levels of IL-1beta in the spleen and mesenteric lymph node, IL-1beta in the thymus, IL-2 in the thymus and spleen, IL-6 in the thymus, IL-10 and IFN-gamma in the spleen, and GM-CSF and TNF-alpha in the thymus decreased after vaccination in rats exposed to ZEA. In conclusion, these results suggest that ZEA exposure via drinking water can cause an immunosuppressive effect by decreasing immunoglobulins in serum and cytokines in lymphoid organs.
