Correlation between CT characteristics and epidermal growth factor receptor mutations in pulmonary adenocarcinoma
10.3969/j.issn.1002-1671.2018.12.012
- VernacularTitle:肺腺癌CT征象与表皮生长因子受体基因突变相关性
- Author:
Liming CHANG
1
;
Zhiyong ZHANG
;
Xuemei LI
;
Haixia LIU
;
Xinyu YANG
;
Limin YAN
;
Chenpeng WU
Author Information
1. 唐山市工人医院 影像科
- Keywords:
lung neoplasm;
adenocarcinoma;
computed tomography;
epidermal growth factor receptor;
mutations
- From:
Journal of Practical Radiology
2018;34(12):1867-1869,1873
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between CT characteristics and epidermal growth factor receptor (EGFR)mutations in pulmonary adenocarcinoma.Methods 82 patients (87 lesions)with pulmonary adenocarcinoma were retrospectively collected.All patients were underwent CT examination before operation,and EGFR gene were determined after operation.Results EGFR mutations were found in 44 of 87 lesions (50.57%).The EGFR mutations rate was 50.00% in females and 47.50% in males,there was no statistical difference between genders (P=0.821).The EGFR mutations rate was 46.55% in the right lung and 58.62% in the left lung,while no statistically significant difference was found (P=0.289).Among all the CT characteristics,the mutations rate was 63.89% in spiculated lesions and 60.71% in lesions with pleural indentation,the differences was statistically significant (P<0.05).The mutations rate was 59.25% in lesions containing solid component and 36.36% in pure ground glass opacity lesions,the difference was statistically significant (P=0.011). There were no statistically differences in lobulation,cavitation and lymphadenectasis (P>0.05).The pleural indentation was the highest in sensitivity (77.27%)and negative predictive value (67.74%).The spiculation was the highest in specificity (69.77%)and positive predictive value (63.89%).Conclusion Among all the CT characteristics,pleural indentation,spiculation and the lesion containing solid component are prone to EGFR mutations.
