Risk factor analysis of benign childhood epilepsy with centrotemporal spikes complicated by electrical status epilepticus in sleep
10.3760/cma.j.issn.2095-428X.2018.24.008
- VernacularTitle:儿童良性癫痫伴中央颞区棘波出现睡眠中癫痫电持续状态危险因素分析
- Author:
Qiang FANG
1
;
Lang CHEN
;
Qiaobin CHEN
;
Feifei WU
;
Jue WANG
;
Zhi LIN
Author Information
1. 福建医科大学附属省立临床医学院儿科
- Keywords:
Benign childhood epilepsy with centrotemporal spikes;
Electrical status epilepticus in sleep;
Risk factor;
Logistic analysis
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(24):1873-1876
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the risk factors for benign childhood epilepsy with centrotemporal spikes (BECT) complicated by electrical status epilepticus in sleep(ESES).Methods From January 2013 to January 2017,a total of 80 children diagnosed as BECT in pediatric neurology outpatient department of Provincial Clinical Medical College Affiliated to Fujian Medical University were enrolled.According to whether there was an attack of ESES or not,patients were divided into ESES group(38 cases) and non-ESES group(42 cases).In order to elucidate risk factors for BECT complicated by ESES,clinical data including age,gender,first seizure age,seizure frequency before treatment,types of seizure,therapeutic drug,recurrence of seizure after treatment,febrile seizure,status at birth,family history,brain MRI,discharge quantity,discharge location,and intelligence score were investigated by multivariate Logistic regression analysis.Results Compared with non-ESES patients,ESES patients were more likely to have recurrence of epilepsy after treatment (68.4％ vs 26.2％,P ＜ 0.001),and had worse intellectual development (＜ 90 scores;73.7％ vs 38.1％,P =0.001);while electroencephalogram showed more discharge in anterior location (47.4％ vs 21.4％,P =0.014) and bilateral distribution of brain (52.6％ vs 26.2％,P =0.015).However,the multivariate Logistic regression analysis showed that only recurrence of seizure after treatment was the risk factor for ESES in BECT patients(P=0.008,OR=4.039,95％CI:1.429-11.418).Conclusion Recurrence of seizure after treatment of BECT was a high risk factor for ESES.Controlling seizure and reducing ESES phenomenon could be beneficial to alleviate the intellectual impairment of patients with BECT.
