Status-quo and advance of hematopoietic stem cell transplantation in childhood leukemia

VernacularTitle:造血干细胞移植治疗儿童白血病现状与进展
Author: Chunfu LI ¹ ; Qi LI
Author Information

1. 南方医科大学南方医院儿科
Keywords: Hematopoietic stem cell transplantation; Leukemia; Child
From: Chinese Journal of Applied Clinical Pediatrics 2014;29(3):168-170
CountryChina
Language:Chinese
Abstract: Hematopoietic stem cell transplantation (HSCT) was used in childhood leukemia for over 30 years.In comparison with chemotherapy,the HSCT benefit,in the early,mainly consisted of human leukocyte antigen (HLA) matched sibling donor (MSD) had not been proven,especially in acute lymphocytic leukemia.As improving and applying of HLA typing high-resolution technology,the survival in HSCT from unrelated donor already closed to those from MSD transplant,and the reducing of relapse rate has been seen.Regarding to haploidentical transplant,the result has been improving with advances in methodology,the applying has been expanding,and the long-term following up is going on.Cell therapy has showed exciting outcomes.