Early diagnosis value of N-terminal pro-brain natriuretic peptide in children with acute lung injury/acute respiratory distress syndrome
10.3760/cma.j.issn.2095-428X.2013.24.014
- VernacularTitle:血浆N末端脑钠素原对儿童急性肺损伤和急性呼吸窘迫综合征的早期诊断价值
- Author:
Xiao LIU
1
;
Yi-Min ZHU
;
Xiu-Lan LU
;
Ping-Ping LIU
Author Information
1. 湖南省儿童医院急救中心
- Keywords:
Acute lung injury;
Acute respiratory distress syndrome;
N-terminal proBNP;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(24):1884-1886
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the early diagnostic value of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in children and its influence on prognosis.Methods Fifty-two children with ALI/ARDS were selected as the experiment group,and 36 children with cardiac disease merging dyspnea were selected as the control group.The serum levels of NT-pro-BNP were measured in the 2 groups.The pediatric critical illness score(PCIS),lung injury score (LIS) and 28-day mortality were analyzed in the experiment group.The serum level of NT-pro-BNP,and the different condition and prognosis were compared in 2 groups,and the difference of the NT-pro-BNP levels were compared in children with ALI/ARDS.Results The NT-proBNP levels in experiment group were significantly higher than the control group (P ＜ 0.05).But the NT-pro-BNP levels in children with cardiaogenic pulmonary edema were significantly higher than ALI/ARDS(P ＜ 0.05).The NT-pro-BNP levels of the children who died in 28 d,or with LIS ＞ 2.5 scores or PCIS≤70 scores were higher than that of children who were survived,or with LIS ≤ 2.5 scores or PCIS ＞ 70 scores (P =0.001,0.013,0.002).The NT-pro-BNP levels were negatively correlated with PCIS(P ＜ 0.05),and the NT-pro-BNP levels were positively correlated with the 28-day mortality and LIS(all P ＜ 0.05).Conclusions The measurement of serum NT-pro-BNP can help to evaluate the severity and prognosis of ALI/ARDS children.
