Association of CHRNA4 and SYN2 gene polymorphism with febrile seizure in the Han Chinese children
10.3760/cma.j.issn.2095-428X.2013.24.008
- VernacularTitle:汉族儿童热性惊厥与CHRNA4和SYN2基因多态性的关联研究
- Author:
Xiao-Tun REN
1
;
Su-Zhen SUN
;
Fang LIU
;
Xiao-Ming WANG
Author Information
1. 100045,首都医科大学附属北京儿童医院神经内科和康复中心
- Keywords:
Febrile seizure;
Single nucleotide polymorphism;
Nicotinic acetylcholine receptor subunit α-4;
Synapsin Ⅱ
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(24):1864-1867
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether single nucleotide polymorphism(SNP) of nicotinic acetylcholine receptor subunit α-4(CHRNA4) or synapsin Ⅱ (SYN2) gene can be used as markers of susceptibility to simple febrile seizure(FS) in the Han children of North China.Methods The CHRNA4 gene rs1044396 and SYN2 gene rs3773364 were genotyped by adopting SNaPshot SNP technique in 141 simple FS children and 130 healthy normal controls.The genotype and allele gene frequency in the 2 groups were compared.Results There were no significant differences in the genotype and allele gene in CHRNA4 gene rs1044396 and SYN2 gene rs3773364 between FS children and healthy controls(all P ＞ 0.05) ; As compared with the FS's clinical data of A/A,A/G,G/G genotypes of the CHRNA4 gene rs1044396 polymorphism and C/C,C/T,T/T genotypes of SYN2 gene rs3773364 polymorphism,there was statistically significant difference in age of first onset in rs 1044396 polymorphism (x2 =17.206,P ＜ 0.001),and there were statistically significant differences in ages and temperature of first onset and gender(x2 =21.458,8.717,10.424,all P ＜0.05) in rs3773364.Conclusions There is no association of CHRNA4 gene rs1044396 polymorphism or SYN2 gene rs3773364 polymorphism with the incidence of simple FS in the Han children of North China,but they may be associated with the age and temperature of first onset.
