Clinical significance of peripheral blood neutrophil CD64 in Kawasaki disease
10.3760/j.issn.2095-428X.2013.21.012
- VernacularTitle:川崎病外周血中性粒细胞CD64表达的临床意义
- Author:
Li-Yun ZHENG
1
;
Rong JIANG
;
Sheng ZHAO
;
Hai-Peng LIU
;
Gui-Ming YANG
;
Bang-Ning CHENG
Author Information
1. 安徽医科大学儿科临床学院安徽省立儿童医院心内科
- Keywords:
Kawasaki disease;
Sepsis;
CD64
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(21):1637-1639
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level of peripheral blood neutrophil CD64 in Kawasaki disease (KD),and explore its clinical significance.Methods Fifty-four patients with KD were divided into 2 groups [13 patients with coronary artery lesions(CAL) and 41 patients without CAL],and 30 age-matched patients with sepsis and 10 healthy children were studied.The levels of peripheral blood neutrophil CD64 was measured by flow cytometry.Results Before treatment,the levels of C D64 in children with KD(7.02 ± 3.21)and sepsis (11.25 ± 5.14) were significantly higher than the healthy children (2.45 ± 0.52),and the level of CD64 in the KD group was significantly lower than that in sepsis group(P ＜ 0.01).CD64 index were significantly elevated in the 2 groups of KD patients before treatment (CAL group:5.74 ± 3.09 ; without CAL:7.43-± 3.17).There was no significant difference in the CD64 level between KD patients with CAL and without CAL.CD64 index in the 2 groups of KD patients after treatment (CAL group:2.56 ± 0.73 ; without CAL:2.63-± 0.69) were significantly lower than those before treatment (all P ＜ 0.01).Conclusions The expression of peripheral blood neutrophil CD64 in KD is significantly elevated.The degree of elevation in CD64 possibly has clinical meaning in differentiating KD from sepsis,and it can be a sensitive factor of disease outcome.
