Relationships between fat mass and obesity associated gene and genetic onset mechanism of obesity in Chinese children
10.3969/cma.j.issn.2095-428X.2013.20.008
- VernacularTitle:脂肪含量和肥胖相关基因与中国儿童肥胖病遗传发病机制的相关性
- Author:
Hai-Dong XU
1
;
Yan-Mei SANG
;
Jie YAN
;
Cheng ZHU
;
Gui-Chen NI
Author Information
1. 100045,首都医科大学附属北京儿童医院新生儿中心
- Keywords:
Obesity;
Fat mass and obesity associated gene;
Gene polymorphism;
Allele;
Genotype
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(20):1544-1547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of fat mass and obesity associated gene(FTO gene) and genetic onset mechanism of obesity in Chinese children.Methods Two hundred and one Chinese children with obesity in Beijing Children's Hospital Affiliated to Capital Medical University from Jan.to Sep.2010,were selected as research subjects,183 healthy adult blood donors were selected as normal controls.Mass Spectrometry techniques were used to study the distributions of the alleles and gene type of FTO in patients and controls.And the relationship between FTO gene polymorphism and obesity in Chinese children were studied.Results The distributions of 5 FTO gene polymorphisms (rs9939609A,rs8050136A,rs3751812T,rs1421085C,rs7193144C) in obesity patients and healthy controls had significant differences.And the Haplotype analysis showed that all of the single nucleotide polymorphisms(SNPs) were in linkage disequilibrium,and three out of six (CTGGTCTGG,TCTGCAAAA,CTGGCCTGG) had significant differences between obesity patients and healthy controls (P ＜ 0.05).Conclusions The gene polymorphisms of rs9939609,rs8050136,rs3751812,rs1421085,rs7193144 of FTO gene confer significant susceptibility to obesity in Chinese children.The haplotypes of CTGGTCTGG,TCTGCAAAA,CTGGCCTGG have significant differences between obesity patients and healthy controls.
