Clinical value of liver biopsy for infantile hepatitis syndrome
10.3969/cma.j.issn.2095-428X.2013.19.015
- VernacularTitle:肝活检病理检查对婴儿肝炎综合征的临床应用价值
- Author:
Mei LONG
1
;
Li ZHU
;
Wen-Li LIU
;
Quan ZHAN
;
Qin-Hui PANG
;
Yan RAO
;
Xiao-Li QUAN
Author Information
1. 550003,贵阳市妇幼保健院儿科
- Keywords:
Infantile hepatitis syndrome;
Ultrasound-guided liver biopsy;
Liver pathology
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(19):1491-1493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of ultrasound-guided liver biopsy for infantile hepatitis syndrome regarding diagnosis,treatment and prognosis.Methods Fifty children with infantile hepatitis syndrome hospitalized in Guiyang Maternal and Child Hospital during Aug.2010 to May 2012 were involved in this study.Ultrasoundguided liver biopsies were performed to evaluate the inflammation grade and fibrosis stage.Immunohistochemical staining was used for pathogen diagnosis.The clinical outcomes were followed-up.Results Thirty-four cases (68％)were CMV infection,6 cases(12％) were vanishing bile duct syndrome,4 cases(8％) were chronic intrauterine infection,4 cases(8％) were congenital anomaly of bilirubin metabolism,and 2 cases (4％) were obstructive cholangitis.All 50 cases showed mild inflammation at portal area(G1-G2 grade).All 50 cases exhibited liver fibrosis.Sixteen cases were S1 stage,20 cases were S2 stage,8 cases were S3 stage and 6 cases were S4 stage.Pathogen analysis:all 50 cases showed intrahepatic cholestasis:38 cases were diffuse cholestasis,and 12 cases were moderate cholestasis.Treatment:all cases were treated using 2-week heteropathy; antivirus was used for CMV infected cases,thus 39 cases were finally cured,9 cases were relieved,and 2 cases were ineffective.Conclusion Liver biopsy is valuable for diagnosis,treatment and prognosis infantile hepatitis syndrome.
