Effect of glutamine on gastrointestinal function in full-term newborn infants with asphyxia
10.3969/cma.j.issn.2095-428X.2013.19.014
- VernacularTitle:谷氨酰胺对窒息足月新生儿肠黏膜屏障功能的影响
- Author:
Xing CHEN
1
;
Yu-Ge HUANG
;
Hai-Ping YIN
;
Xiu-Lan HUANG
;
Xue-Hui ZHENG
;
Zhen LI
;
Hong LIANG
Author Information
1. 成都市第三人民医院儿科
- Keywords:
Glutamine;
Asphyxia;
Neonate;
Intestinal barrier function;
Clinical study
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(19):1487-1490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of bowel functions in mild asphyxial full-term neonates and evaluate the possible effect of glutamine (Gln) on intestinal barrier function.Methods A prospective,blind,randomized controlled clinical study was conducted in neonatal ward and maternity ward of the Affiliated Hospital of Guangdong Medical College.Thirty-seven mild asphyxial neonates and 15 normal neonates were included.The 37 asphyxiated term infants were randomly divided into 2 groups:asphyxia group and asphyxia control group.The 20 infants in the asphyxia group were given Gln [0.3 g/(kg · d)] based on supporting treatment,added in breast milk or formula,3 times in daily.The 17 infants in asphyxia control group were fed with equal amount of 9 g/L saline supplementation.The same term 15 normal neonates as healthy control group were breast fed in obstetrics.The intervention lasted 1 week.Blood samples were collected from the 3 groups on day 1,3 and 7.The serum DAO and D-lactic acid levels were detected to evaluate the gastrointestinal function.Results Demographic and management characteristics of the 3 groups were similar.And there was no difference(P ＞0.05) between asphyxial neonates and normal neonates in clinical manifestation,including type of feeding,delivery mode,etc.A statistical difference (P ＜ 0.05) was found in factors of amniotic fluid turbidity and umbilical cord between asphyxial control group and healthy control group.Compared with asphyxia control study,the content of serum DAO and D-lactic acid on day 1,day 3,day 7 were clearly lower in healthy control group,and the differe-nces were statistically significant(all P ＜ 0.05).The levels of DAO and D-lactic acid in healthy control group were significantly lower than those of asphyxia control group (all P ＜ 0.05).No adverse effect or treating intolerance were noted.Conclusions Mild asphyxia neonatorum impaired the gut barrier function.Compared with placebo,glutamine supplementation can improve the intestinal mucosal barrier function to bettery recovery in asphyxial neonates.
