Expression of soluble platelet endothelial cell adhesion molecule-1 and P-selectin and the significance in children with autism
10.3760/cma.j.issn.2095-428X.2013.18.016
- VernacularTitle:可溶性血小板内皮细胞黏附分子1及P选择素在孤独症患儿中的表达及其意义
- Author:
Jian-Qiang XU
1
;
Su-Qin GUO
;
Kui NING
;
Hong-Xia XI
Author Information
1. 453002,新乡医学院第二附属医院精神五科
- Keywords:
Soluble platelet endothelial cell adhesion molecule-1;
P-selectin;
Autism
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(18):1415-1416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of soluble platelet endothelial cell adhesion molecule-1 (PECAM-1) and P-selectin and the clinical significance in autistic children.Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect serum PECAM-1 and P-selectin levels in 12 autistic children and 15 healthy children,the autistic children were scored by using Antecedent Behavior Consequence (ABC) Chart,and correlation analysis of PECAM-1 and ABC Chart was performed.Results The PECAM-1 level in autistic children was higher than that in healthy control group(t =2.06,P < 0.05),and the P-selectin level was lower than that in healthy control group (t =2.05,P < 0.05),at the same time,PECAM-1 level was positively correlated with the ABC scores in autistic children (r =0.67,P =0.017).Conclusions PECAM-1 as a representation of the immune system immune factors may be involved in the central nervous immune process of autistic children,which is related to ABC chart scores of autistic children.Also it prompts that autism is related to immune factors.