Expressions of hypoxia inducible factor-1α and angiopoietin-2 in pediatric nephroblastoma
10.3760/cma.j.issn.2095-428X.2013.15.021
- VernacularTitle:缺氧诱导因子-1α、促血管生成素-2在小儿肾母细胞瘤中的表达
- Author:
Chun-Qiang DONG
1
;
Ti-Quan YANG
;
Kun DONG
Author Information
1. 广西医科大学第一附属医院小儿外科
- Keywords:
Hypoxia-inducible factor-1α;
Angiopoietin-2;
Microvessel density;
Nephroblastoma;
Prognosis
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(15):1191-1194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions ofhypoxia-inducible factor-1α(HIF-1α) and angiopoietin-2 (Ang-2) in children with nephroblastoma (NB) and its correlation with clinicopathology,prognosis and microvessel density(MVD).Methods Forty-five cases of NB treated by Pediatric Surgery Department of the First Affiliated Hospital of Guangxi Medical University,with NB resected from Jan.2008 to Jan.2012,were divided into groups according to histopathological type,clinical stage and National Wilm's Tumor Study-5 risk factors.The expressions of HIF-1α,Ang-2 and CD34/MVD in NB tissues and adjacent tissues were tested by immunohistochemical method,and the findings were analyzed with the combination of the clinical data and results of the follow-up.Results The ratio of HIF-1α and Ang-2 expressions in NB group was higher than that in the normal adjacent tissues(95.6％ vs 40％ and 86％ vs31.0％,respectively,P ＜ 0.05).HIF-1α and Ang-2 expressions were positively correlated with clinic stage and risk factors,and the postoperative cumulated survival rate was higher in low expression group of HIF-1α,Ang-2 compared with the higher expression group of HIF-1α,Ang-2 (P ＜ 0.05).MVD was higher in NB group than in normal adjacent tissue groups (58.22 ± 10.009 vs 49.43 ±-8.114,P＜0.05) and had a positive correlation with HIF-1α(r =0.442,P＜0.05) and Ang-2 (r =0.590,P ＜ 0.05).HIF-1α had a positive correlation with Ang-2 (r =0.442,P ＜ 0.05).Conclusion HIF-1α and Ang-2 could promote angiogenesis and proliferation in NB,which affects the prognosis.
