Parvovirus B19-induced Pure Red Cell Aplasia in a Liver Transplant Recipient.
10.3343/kjlm.2010.30.6.591
- Author:
Eun Young LEE
1
;
Yonggeun CHO
;
Sang Guk LEE
;
Jaewoo SONG
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. labdx@yuhs.ac
- Publication Type:Case Report ; English Abstract
- Keywords:
Pure red cell aplasia;
Parvovirus B19;
Human;
Liver transplantation
- MeSH:
Blood Transfusion;
Bone Marrow/pathology;
Carcinoma, Hepatocellular/etiology/therapy;
DNA, Viral/analysis;
Female;
Hepatitis C/complications/diagnosis;
Humans;
Immunocompromised Host;
Immunoglobulins/therapeutic use;
Liver Neoplasms/etiology/therapy;
Liver Transplantation;
Middle Aged;
Parvoviridae Infections/complications/*diagnosis;
*Parvovirus B19, Human/genetics;
Red-Cell Aplasia, Pure/*diagnosis/therapy/virology
- From:The Korean Journal of Laboratory Medicine
2010;30(6):591-594
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Parvovirus B19 infection is known to cause chronic anemia in immunocompromised hosts, including organ transplant recipients. We report the first case of liver transplant recipient with parvovirus B19-induced pure red cell aplasia in Korea. A 57-yr-old female patient with hepatocellular carcinoma due to hepatitis C virus received a liver transplantation. Two months later, anemia developed and she received periodic red blood cell transfusions. However, chronic anemia persisted and bone marrow examination was performed 8 months after transplantation. Bone marrow aspiration smears showed markedly reduced erythroid precursors with atypical giant pronormoblasts and nuclear remnants with viral inclusions, and characteristic lantern cells were observed in biopsy sections. In addition, parvovirus B19 DNA PCR was positive. She was diagnosed as parvovirus B19-induced pure red cell aplasia and her anemia was improved following intravenous immunoglobulin therapy.
