Clinical features of hepatitis associated aplastic anemia for children by eviden ce-based medical analysis
10.3760/cma.j.issn.2095-428X.2013.15.011
- VernacularTitle:儿童肝炎相关再生障碍性贫血循证医学分析
- Author:
Xiao-Hong QIAO
1
;
Xiao-Tian XIE
;
Wei SHI
;
Yue-Xia SHAO
;
Shuang-Long LU
;
Chang-Juan GU
Author Information
1. 同济大学附属同济医院儿科
- Keywords:
Aplastic anemia;
Hepatitis;
Clinical feature;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2013;28(15):1155-1158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical features and curative effect of hepatitis associated aplastic anemia (HAAA) in children of China.Methods Patients' records in China Biological Medicine Database (CBM-disc 1980-2011) and Wan Fang Database were reviewed.The clinical data of the children with newly diagnosed HAAA were respectively studied,including clinical manifestations,blood routine,bone marrow examination and viral serology results,as well as the treatment and clinical effect.Results A total of 50 children were confirmed as HAAA.There were 41 boys and 9 girls.The median age was 8.2 years(range 0.8 to 15.0 years) on diagnosis.The causes of hepatitis could not be identified.The median interval between hepatitis occurrence to blood cell reduction was 10 weeks.Twenty-two cases were diagnosed as severe aplastic anemia and 13 cases as very severe aplastic anemia.Fifteen children died within 1 month after diagnosis.In the immunosuppression treatment group,the percentage of overall responders was 69.2％,which was higher than that of the non-immunosuppression treatment group (18.5％) (x2 =9.920,P ＜ 0.01).Conclusions Severe HAAA is very common in school children,especially in boys.The children with HAAA have a higher early death rate.Immunosuppression therapy is effective if combined with androgenic hormone with an earlier diagnosis.
